Pharmacology and Toxicology

Mitragynine and 7-Hydroxymitragynine: Bidirectional Effects on Breathing in Rats

Mitragynine and 7-Hydroxymitragynine: Bidirect...

Pharmacology and Toxicology
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Samuel Obeng
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Differential responses of murine embryonic stem cells (mESC) and their endothelial progeny to doxorubicin and pharmacological inhibitors of DNA repair and DNA damage response

Differential responses of murine embryonic ste...

Pharmacology and Toxicology
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librarian
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The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels

The sodium/glucose cotransporter 2 inhibitor e...

Pharmacology and Toxicology
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Karlheinz Hilber
3 views
CHI3L1-Targeted Small Molecules as Glioblastoma Therapies: Virtual Screening-Based Discovery, Biophysical Validation, Pharmacokinetic Profiling, and Evaluation in Glioblastoma Spheroids

CHI3L1-Targeted Small Molecules as Glioblastom...

Pharmacology and Toxicology
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librarian
7 views
Promising protocol for in vivo experiments with betulin

Promising protocol for in vivo experiments wit...

Pharmacology and Toxicology
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librarian
2 views
Discovery and structure-activity relationship analysis of 2-Pyridyl Thienopyrimidine derivatives as promising therapeutic candidates for the treatment of Buruli ulcer

Discovery and structure-activity relationship ...

Pharmacology and Toxicology
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Fabrice Boyom
5 views
Theanine boosts frontal theta and hippocampal beta and gamma oscillations for familiarity in object recognition

Theanine boosts frontal theta and hippocampal ...

Pharmacology and Toxicology
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Nobuyoshi Matsumoto
4 views
High-resolution imaging reveals a cascade of interconnected cellular bioeffects differentiating the long-term fates of sonoporated cells

High-resolution imaging reveals a cascade of i...

Pharmacology and Toxicology
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Pranesh Padmanabhan
6 views
Screening for cryoprotective agent toxicity and toxicity reduction in mixtures at subambient temperatures

Screening for cryoprotective agent toxicity an...

Pharmacology and Toxicology
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librarian
5 views
A Mechanism Based Pharmacokinetic/Pharmacodynamic Analysis of Polymyxin B-Based Combination Therapy Against Carbapenem-Resistant Klebsiella pneumoniae Isolates with Diverse Phenotypic and Genotypic Resistance Mechanisms

A Mechanism Based Pharmacokinetic/Pharmacodyna...

Pharmacology and Toxicology
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librarian
8 views
Synaptic Toxicity of OGA Inhibitors and the Failure of Ceperognastat

Synaptic Toxicity of OGA Inhibitors and the Fa...

Pharmacology and Toxicology
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librarian
7 views
Role of adipocyte angiotensinogen or angiotensin type 1a receptors in the development of diet-induced atherosclerosis or angiotensin II-induced abdominal aortic aneurysms

Role of adipocyte angiotensinogen or angiotens...

Pharmacology and Toxicology
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librarian
8 views
Advanced Cardiac Organoid Model for Studying Doxorubicin-Induced Cardiotoxicity

Advanced Cardiac Organoid Model for Studying D...

Pharmacology and Toxicology
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Xian Wu
7 views
High-Throughput Evaluation of Cryoprotective Agents for Mixture Effects That Reduce Toxicity

High-Throughput Evaluation of Cryoprotective A...

Pharmacology and Toxicology
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librarian
8 views
Evaluation of the Basis and Performance of Simple Allometry for Predictions of Clearance and Oral Clearance in Humans and Improvement Potential with Added In Silico Predictions

Evaluation of the Basis and Performance of Sim...

Pharmacology and Toxicology
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librarian
10 views
Anti-Sense Oligonucleotide as a Therapeutic for Synucleinopathies: Pharmacokinetic, Safety and Efficacy Evaluation

Anti-Sense Oligonucleotide as a Therapeutic fo...

Pharmacology and Toxicology
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librarian
11 views
Hybrid Population PK-Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn's Disease

Hybrid Population PK-Machine Learning Modeling...

Pharmacology and Toxicology
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librarian
11 views
Consumption of clinically relevant cannabidiol doses during pregnancy alters postnatal behavior in offspring

Consumption of clinically relevant cannabidiol...

Pharmacology and Toxicology
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librarian
9 views
Single-Shot Design of a Cyclic Peptide Inhibitor of HIV-1 Membrane Fusion with EvoBind

Single-Shot Design of a Cyclic Peptide Inhibit...

Pharmacology and Toxicology
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librarian
17 views
Development and Validation of a Stem Cell-Based Kidney Organoid Platform for Nephrotoxicity Assessment

Development and Validation of a Stem Cell-Base...

Pharmacology and Toxicology
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librarian
9 views
Profiling of HCAR1 signaling reveals Gαi/o and Gαs activation without β-arrestin recruitment and the discovery of an allosteric agonist

Profiling of HCAR1 signaling reveals Gαi/o and...

Pharmacology and Toxicology
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librarian
8 views
Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis

Alignment between Duplex Sequencing and transg...

Pharmacology and Toxicology
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Anne Ashford
10 views
Early-life PBDE flame retardant exposures cause neurobehavioral alterations in fish that persist into adulthood and vary by sex and route of exposure

Early-life PBDE flame retardant exposures caus...

Pharmacology and Toxicology
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librarian
11 views
PBDE flame retardant exposure causes neurobehavioral and transcriptional effects in first-generation but not second-generation offspring fish

PBDE flame retardant exposure causes neurobeha...

Pharmacology and Toxicology
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Andrew Whitehead
11 views
SynVerse: A Framework for Systematic Evaluation of Deep Learning Based Drug Synergy Prediction Models

SynVerse: A Framework for Systematic Evaluatio...

Pharmacology and Toxicology
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librarian
9 views
GenVS TBDB: An Open AI-Generated andVirtual Screened Small-Molecule Database for Tuberculosis Drug Discovery

GenVS TBDB: An Open AI-Generated andVirtual Sc...

Pharmacology and Toxicology
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librarian
11 views
Rapid, open-source, and automated quantification of the head twitch response in C57BL/6J mice using DeepLabCut and Simple Behavioral Analysis

Rapid, open-source, and automated quantificati...

Pharmacology and Toxicology
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Grant Glatfelter
10 views
Cortical reactive microglia activate astrocytes, increasing neurodegeneration in human alcohol use disorder

Cortical reactive microglia activate astrocyte...

Pharmacology and Toxicology
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Fulton Crews
15 views
Nanotechnology-Driven Synergy: Research Effects of Curcumin Nanosuspension and Fluconazole Combination in Overcoming Azole Resistance in Candida Albicans

Nanotechnology-Driven Synergy: Research Effect...

Pharmacology and Toxicology
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Cheng Zhang
13 views
Exploring Phage-Staphylococcus aureus Host Dynamics Through Innovative In Vitro Experiment and Pharmacokinetic/pharmacodynamic Modeling

Exploring Phage-Staphylococcus aureus Host Dyn...

Pharmacology and Toxicology
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librarian
14 views
RSPO2-based peptibodies conjugated with pyrrolobenzodiazepine dimer or camptothecin analogs demonstrate potent anti-tumor activity by targeting the three receptors LGR4/5/6

RSPO2-based peptibodies conjugated with pyrrol...

Pharmacology and Toxicology
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librarian
13 views
An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

An Enantioselective Chemical Probe for Chikung...

Pharmacology and Toxicology
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librarian
12 views
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