Pharmacology and Toxicology

DSPE-PEG does not retain targeting antibodies on LNP surfaces in vivo; a higher molecular weight anchor is required

DSPE-PEG does not retain targeting antibodies ...

Pharmacology and Toxicology
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librarian
3 views
Green-synthesized silver nanoparticles enhance Guibourtia tessmannii antithromboinflammatory therapeutic potential

Green-synthesized silver nanoparticles enhance...

Pharmacology and Toxicology
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librarian
8 views
Novel apoptosis signal-regulating kinase 1 (ASK1) inhibitor SRT-015: Potential therapeutic for multiple liver diseases

Novel apoptosis signal-regulating kinase 1 (AS...

Pharmacology and Toxicology
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Kathleen Elias
12 views
β-alanine betaine and nAChRs in Ascaris

β-alanine betaine and nAChRs in Ascaris

Pharmacology and Toxicology
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librarian
13 views
The effects of estrogen exposure on survival, growth, and fecundity of Daphnia magna

The effects of estrogen exposure on survival, ...

Pharmacology and Toxicology
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S Schaack
26 views
Basal Internalization and Subcellular Localization of XCR1

Basal Internalization and Subcellular Localiza...

Pharmacology and Toxicology
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Fernando Salgado-Polo
19 views
Enhanced TRPV1 activation through TLR-4 and PKA signaling in Dorsal Root Ganglia Neurons

Enhanced TRPV1 activation through TLR-4 and PK...

Pharmacology and Toxicology
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librarian
27 views
Dose optimisation of favipiravir against RNA viruses using physiologically-based pharmacokinetic modelling.

Dose optimisation of favipiravir against RNA v...

Pharmacology and Toxicology
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librarian
35 views
Modular in vitro evaluation of Buparlisib-polymeric nanomedicines in 2D and 3D models of glioblastoma

Modular in vitro evaluation of Buparlisib-poly...

Pharmacology and Toxicology
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Jarmila Havelkova
33 views
Next Generation TB Drug Combinations from the Pan-TB Consortium: Combination Efficacy and Contributions of Individual Agents, Evaluated in a BALB/c Mouse TB Model

Next Generation TB Drug Combinations from the ...

Pharmacology and Toxicology
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librarian
33 views
Pharmaceutical TAS2R14 Agonists Display Diverse Potency, Efficacy, and Binding-Site Sensitivity

Pharmaceutical TAS2R14 Agonists Display Divers...

Pharmacology and Toxicology
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Masha Y Niv
30 views
Orally Bioavailable SARS-CoV-2 Protease Inhibitors Bearing a Hydroxymethyl Ketone Warhead

Orally Bioavailable SARS-CoV-2 Protease Inhibi...

Pharmacology and Toxicology
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librarian
85 views
A Cherry-Flavoured E-Cigarette Adduct, BPGA, Reprograms Alveolar Epithelial Cell Fate Through Epithelial-to-Mesenchymal Transition and Evasion of Apoptosis

A Cherry-Flavoured E-Cigarette Adduct, BPGA, R...

Pharmacology and Toxicology
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librarian
91 views
ERRγ deletion in podocytes accelerates aging related kidney disease

ERRγ deletion in podocytes accelerates aging r...

Pharmacology and Toxicology
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librarian
85 views
Comparative metabolism of the Alternaria toxins altenuene and tentoxin in rat and human primary hepatocytes

Comparative metabolism of the Alternaria toxin...

Pharmacology and Toxicology
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librarian
90 views
Cyclic Peptides Target CAPON and Modulate Cellular Responses under Alzheimers Disease-Relevant Stress

Cyclic Peptides Target CAPON and Modulate Cell...

Pharmacology and Toxicology
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librarian
87 views
Integrated luminescence and phenotypic profiling for drug discovery in a zebrafish model of Marfan syndrome

Integrated luminescence and phenotypic profili...

Pharmacology and Toxicology
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librarian
78 views
Activation by statins unveils two putative agonist binding sites in the pore domain of TRPA1

Activation by statins unveils two putative ago...

Pharmacology and Toxicology
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librarian
102 views
Ramelteon facilitates hippocampal ripple occurrence and amplitude in mice

Ramelteon facilitates hippocampal ripple occur...

Pharmacology and Toxicology
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librarian
98 views
Systematic toxicological study of PFOS/PFOA co-exposure driving prostate cancer: Core target identification, TME immune remodeling, and combination drug prediction

Systematic toxicological study of PFOS/PFOA co...

Pharmacology and Toxicology
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Jian SHI
88 views
Virtual screening and zebrafish phenotype-based evaluation argues against repurposing 4-phenylbutyrate for STXBP1-relateddisorders

Virtual screening and zebrafish phenotype-base...

Pharmacology and Toxicology
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Scott Baraban
88 views
Reversible in vivo regulation of drug metabolizing enzyme CYP1A2 activity through a dTAG knock-in strategy

Reversible in vivo regulation of drug metaboli...

Pharmacology and Toxicology
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librarian
97 views
Railway Catenary Sparking as a Source of Toxic Copper Ultrafine Particles: Evidence from Realistic In Vitro Inhalation Exposure

Railway Catenary Sparking as a Source of Toxic...

Pharmacology and Toxicology
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Sebastiano Di Bucchianico
92 views
Sex-specific amplification of IKr-blocker-induced action potential prolongation by reduced female IKs repolarization reserve: a computational study using the O'Hara-Rudy human ventricular model

Sex-specific amplification of IKr-blocker-indu...

Pharmacology and Toxicology
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Tarun Aadithya Raghavan
83 views
Deciphering the Caffeine-Specific Neuroprotective Axis: Comparative Docking and Pharmacokinetic Evaluation of the Coffee Phytocomplex

Deciphering the Caffeine-Specific Neuroprotect...

Pharmacology and Toxicology
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librarian
95 views
Acute Exposure to Perfluorooctanoic Acid (PFOA) During Cardiomyogenesis disrupts Transcriptional and Electrophysiological Profiles in Differentiated Myocytes

Acute Exposure to Perfluorooctanoic Acid (PFOA...

Pharmacology and Toxicology
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librarian
101 views
Model-supported patient stratification using multi-objective synergy optimization in combination therapy

Model-supported patient stratification using m...

Pharmacology and Toxicology
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librarian
99 views
Development of approaches to overcome the drop in hematocrit when implementing mononuclear phagocyte system cytoblockade in vivo used to prolong the circulation of nanoparticles in the blood

Development of approaches to overcome the drop...

Pharmacology and Toxicology
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Elizaveta Mochalova
103 views
Tocilizumab induces significant changes in longitudinal proteomes of blood serum from patients with severe COVID-19 pneumonia

Tocilizumab induces significant changes in lon...

Pharmacology and Toxicology
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librarian
98 views
Effects of the Mu Opioid Receptor Positive Allosteric Modulator BMS-986122 On Opioid Efficacy in Rat Neuropathic Pain States

Effects of the Mu Opioid Receptor Positive All...

Pharmacology and Toxicology
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John Traynor
102 views
Development of NanoBRET cellular target engagement assays in primary neurons for activating mutants of p21-activated kinase 1

Development of NanoBRET cellular target engage...

Pharmacology and Toxicology
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librarian
102 views
Mutation-Induced Pocket Deactivation: How Ser353/Pro245 Alters KCa2.2 vs KCa3.1 Ligand Selectivity

Mutation-Induced Pocket Deactivation: How Ser3...

Pharmacology and Toxicology
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Oliver Koch
103 views
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