Pharmacology and Toxicology

Understanding the kinetics of macrophage uptake and the metabolic fate of iron-carbohydrate complexes used for iron deficiency anemia treatment

Understanding the kinetics of macrophage uptak...

Pharmacology and Toxicology
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librarian
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N-Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad Spectrum Antialphaviral Activity

N-Alkyl Sulfamates as a New Class of nsP2 Cyst...

Pharmacology and Toxicology
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librarian
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Comparative toxicity of menthol- and tobacco-flavored electronic cigarette constituents causing inflammation, epithelial barrier dysfunction, and nicotinic acetylcholine receptor modulation in the absence of nicotine.

Comparative toxicity of menthol- and tobacco-f...

Pharmacology and Toxicology
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Thivanka Muthumalage
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Functionalization of lipid nanoemulsions with humanized antibodies using plug-and-play cholesterol anchor for targeting cancer cells

Functionalization of lipid nanoemulsions with ...

Pharmacology and Toxicology
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librarian
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Developmental PBDE exposure impairs histamine release dynamics in adult male and female mice via disrupted granule maturation and calcium mobilization

Developmental PBDE exposure impairs histamine ...

Pharmacology and Toxicology
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librarian
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Decoding Cellular Stress States for Toxicology Using Single-Cell Transcriptomics

Decoding Cellular Stress States for Toxicology...

Pharmacology and Toxicology
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librarian
40 views
Metadimensional simulation for biochemistry and pharmacology learning

Metadimensional simulation for biochemistry an...

Pharmacology and Toxicology
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Thomaz Rocha e Silva
58 views
Evaluation of graphene oxide-mediated NET formation using HL-60-derived neutrophil-like cells

Evaluation of graphene oxide-mediated NET form...

Pharmacology and Toxicology
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Kiyoshi Fukuhara
78 views
Simpatico: accurate and ultra-fast virtual drug screening with atomic embeddings

Simpatico: accurate and ultra-fast virtual dru...

Pharmacology and Toxicology
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Jeremiah Gaiser
77 views
Stereospecific rapid activation of Transcription Factor EB (TFEB) by Levacetylleucine (NALL)

Stereospecific rapid activation of Transcripti...

Pharmacology and Toxicology
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Antony Galione
75 views
Contrastive learning of adverse events to provide effective and interpretable vector representations for machine-assisted pharmacovigilance

Contrastive learning of adverse events to prov...

Pharmacology and Toxicology
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librarian
77 views
Inhibiting RhoA Activation via GDP-state Stabilization to Relieve Heart Failure

Inhibiting RhoA Activation via GDP-state Stabi...

Pharmacology and Toxicology
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Yong Wang
94 views
SLAB: Simultaneous Labeling And Binding affinity prediction for protein-ligand structures

SLAB: Simultaneous Labeling And Binding affini...

Pharmacology and Toxicology
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librarian
98 views
TREM2 Hit Discovery Using TRIC Technology: A Proof-of-Concept High-Throughput Screening Approach

TREM2 Hit Discovery Using TRIC Technology: A P...

Pharmacology and Toxicology
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librarian
102 views
Evolving resistance patterns in Tetranychus urticae and Bemisia tabaci in Greece

Evolving resistance patterns in Tetranychus ur...

Pharmacology and Toxicology
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librarian
111 views
Determination of chemical partitioning in vehicles using a skin surrogate for dermal absorption model refinement.

Determination of chemical partitioning in vehi...

Pharmacology and Toxicology
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librarian
124 views
Stochastic gates for covariate selection in population pharmacokinetics modelling

Stochastic gates for covariate selection in po...

Pharmacology and Toxicology
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librarian
119 views
Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28

Rules of engagement: determinants of chemokine...

Pharmacology and Toxicology
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librarian
124 views
Oxidative stress and vacuolar variants influence paraquat response in Saccharomyces cerevisiae of different genetic variants

Oxidative stress and vacuolar variants influen...

Pharmacology and Toxicology
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Andres Klein
125 views
IQM-22110 as a selective KV4.3/KChIP3 modulator. Molecular determinants of the KChIP3 binding site

IQM-22110 as a selective KV4.3/KChIP3 modulato...

Pharmacology and Toxicology
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librarian
129 views
Non-Equilibrium Snapshots of Ligand Efficacy at the μ-Opioid Receptor

Non-Equilibrium Snapshots of Ligand Efficacy a...

Pharmacology and Toxicology
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Georgios Skiniotis
125 views
Validation of a high-throughput screening assay for the characterization of cryoprotective agent toxicity

Validation of a high-throughput screening assa...

Pharmacology and Toxicology
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Rebecca Sandlin
125 views
Discovery and Development of DC-174 as a Novel Oral Snakebite Treatment

Discovery and Development of DC-174 as a Novel...

Pharmacology and Toxicology
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librarian
133 views
In-dwelling microfluidic device for precise and reliable intranasal drug delivery during freely-moving behavior

In-dwelling microfluidic device for precise an...

Pharmacology and Toxicology
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librarian
127 views
TRPV4 activation enhances LPS-induced IL10 production to suppress excessive microglial activation

TRPV4 activation enhances LPS-induced IL10 pro...

Pharmacology and Toxicology
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librarian
129 views
Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

Mechanism of SK2 channel gating and its modula...

Pharmacology and Toxicology
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librarian
127 views
Neurotoxicity of Propylene Glycol Butyl Ether: Multiomic Evidence from Human BrainSpheres

Neurotoxicity of Propylene Glycol Butyl Ether:...

Pharmacology and Toxicology
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Marie-Gabrielle Zurich
365 views
Endothelial c-IAP2 Loss Amplifies P2X7 Receptor-Driven Inflammation and Worsens Infection-Associated Pulmonary Hypertension

Endothelial c-IAP2 Loss Amplifies P2X7 Recepto...

Pharmacology and Toxicology
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Suellen Oliveira
124 views
Identification of antibody-drug conjugate payloads which are substrates of ATP-binding cassette drug efflux transporters

Identification of antibody-drug conjugate payl...

Pharmacology and Toxicology
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Matthew Hall
128 views
Identification of new KCNT1-epilepsy drugs by in silico, cell and Drosophila modelling.

Identification of new KCNT1-epilepsy drugs by ...

Pharmacology and Toxicology
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Jonathan Lippiat
141 views
Intranasal Dantrolene Nanoparticles for Treatment of Amyotrophic Lateral Sclerosis as a Disease-Modifying Drug

Intranasal Dantrolene Nanoparticles for Treatm...

Pharmacology and Toxicology
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librarian
135 views
Bisdemethoxycurcumin mitigates Alzheimer disease pathology through autophagy-mediated reduction of senescence and amyloid beta

Bisdemethoxycurcumin mitigates Alzheimer disea...

Pharmacology and Toxicology
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Ajay Kumar
132 views
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