Systems Biology

Scalable longitudinal imaging and transcriptomics of cells in dynamic enclosures

Scalable longitudinal imaging and transcriptom...

Systems Biology
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Mostafa Ronaghi
4 views
Mathematical Modeling of the Canonical Aryl Hydrocarbon Receptor Pathway

Mathematical Modeling of the Canonical Aryl Hy...

Systems Biology
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librarian
3 views
Ensemble kinetic modelling links residual enzyme activity to clinical symptoms in mitochondrial β-oxidation defects

Ensemble kinetic modelling links residual enzy...

Systems Biology
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librarian
3 views
A unified framework links infant vulnerability with aging-related mortality dynamics

A unified framework links infant vulnerability...

Systems Biology
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librarian
4 views
COCOA.jl: A Julia package for high-performance analysis of concordance and kinetic modules in biochemical networks

COCOA.jl: A Julia package for high-performance...

Systems Biology
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librarian
3 views
Robotic perturbation proteomics and AI agents enable scalable drug mechanism discovery

Robotic perturbation proteomics and AI agents ...

Systems Biology
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Yuming Jiang
8 views
Multi-omic analysis identifies mitochondrial dysfunction as a conserved driver of acute severity and long-term complications in RSV infection

Multi-omic analysis identifies mitochondrial d...

Systems Biology
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librarian
6 views
Bion-M 2 Biosatellite: Multisystem Mouse Responses to 30 Days in High-Latitude Orbit as a Deep-Space Analog

Bion-M 2 Biosatellite: Multisystem Mouse Respo...

Systems Biology
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librarian
7 views
Box-Counting Fractal Dimensions of Cranial Suture: Effects of Measurement Conditions and Model-Based Reproduction of Fractal-Like Patterns

Box-Counting Fractal Dimensions of Cranial Sut...

Systems Biology
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Takashi Miura
9 views
Lineage-specific lncRNAs critically determine cross-species differences in tumors

Lineage-specific lncRNAs critically determine ...

Systems Biology
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librarian
10 views
REDUCED-PRECISION STOCHASTIC SIMULATION FOR MATHEMATICAL BIOLOGY

REDUCED-PRECISION STOCHASTIC SIMULATION FOR MA...

Systems Biology
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librarian
10 views
Network topology dictates sequential drug efficacy through bistability-mediated state switching

Network topology dictates sequential drug effi...

Systems Biology
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librarian
8 views
The Limits of Cross-Species WGCNA: Library Imbalance and Signal Dilution Constrain Effector Gene Recovery in Dual-Organism RNA-seq

The Limits of Cross-Species WGCNA: Library Imb...

Systems Biology
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librarian
10 views
Systems modeling identifies phenotype-determining signaling pathways controlled by phosphatase PTPRJ in diverse receptor tyrosine kinase activation settings

Systems modeling identifies phenotype-determin...

Systems Biology
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librarian
12 views
A Scalable Sign-Aware Multi-Omics Knowledge Graph Foundation Model for Mechanistic Drug Action and Clinical Response Predictions

A Scalable Sign-Aware Multi-Omics Knowledge Gr...

Systems Biology
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Lei Xie
9 views
A Comprehensive Mathematical Model of Avidity in Cytokine Signaling

A Comprehensive Mathematical Model of Avidity ...

Systems Biology
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librarian
11 views
A low-dimensional transcriptional code enables decoding of BMP/TGFβ signaling from single-cell transcriptomes

A low-dimensional transcriptional code enables...

Systems Biology
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librarian
26 views
A transcriptional patient map of systemic lupus erythematosus reveals disease-related multicellular immune programs conserved between blood and kidney

A transcriptional patient map of systemic lupu...

Systems Biology
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librarian
22 views
A unified framework for causal gene regulatory network inference grounded in orthogonal molecular evidence

A unified framework for causal gene regulatory...

Systems Biology
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B. Franklin Pugh
23 views
Bidirectional network hubs: NT-genes as optimal targets for partial cancer reversal

Bidirectional network hubs: NT-genes as optima...

Systems Biology
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Augusto Gonzalez
23 views
DrugPTM-Bench: A Large-Scale Dataset for Predictive Modeling of Drug-Induced Cell Type-Specific Protein Post-Translational Modifications

DrugPTM-Bench: A Large-Scale Dataset for Predi...

Systems Biology
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Amitesh Badkul
27 views
Aging Rhesus Macaque show tissue and sex-specific balance of drifting and coordinated miRNA programs

Aging Rhesus Macaque show tissue and sex-speci...

Systems Biology
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librarian
23 views
A Minimal Regulatory Spatial Model for Emergent Multicellular Organization in Dissipative Environments

A Minimal Regulatory Spatial Model for Emergen...

Systems Biology
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librarian
24 views
Proteome-aware organ proxy aging clocks

Proteome-aware organ proxy aging clocks

Systems Biology
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librarian
35 views
Data-driven lifespan transitions: cortical morphometry and intrinsic differences across network scales

Data-driven lifespan transitions: cortical mor...

Systems Biology
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Rose Cuthbertson
28 views
Defining Cell Types through Maximally Informative Biological Atlases

Defining Cell Types through Maximally Informat...

Systems Biology
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Roy Wollman
26 views
Impact of variability in cell generation times on cell-to-cell variability of protein concentrations

Impact of variability in cell generation times...

Systems Biology
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librarian
27 views
HyperMap: An Efficient Framework for Transferring Perturbation Responses Across Diverse Biological Contexts

HyperMap: An Efficient Framework for Transferr...

Systems Biology
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librarian
27 views
Extreme genome reduction selectively retains modular regulatory architecture in Prochlorococcus MED4: conserved transcriptional modules reveal core physiological regulatory programs

Extreme genome reduction selectively retains m...

Systems Biology
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Pavlo Bohutskyi
32 views
Orchard management alters citrus root and rhizosphere microbiomes with functional consequences for plant performance

Orchard management alters citrus root and rhiz...

Systems Biology
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M. Caroline Roper
38 views
SEC-seq reveals translation-focused metabolic strategies for high IgG productivity in clonal CHO cells

SEC-seq reveals translation-focused metabolic ...

Systems Biology
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librarian
33 views
Serum protein profiling reveals hallmark-level aging trajectories and strain-specific resilience in CB6F1J and C57BL/6J male mice.

Serum protein profiling reveals hallmark-level...

Systems Biology
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librarian
38 views
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